Modelling of morphogenesis to support the design of fungal-based engineered living materials

Vilhelm Carlström; Adrien Rigobello; Phil Ayres

doi:10.1017/btd.2024.10

Modelling of morphogenesis to support the design of fungal-based engineered living materials

Publications: Contribution to journal › Journal article › Research › peer-review

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Abstract

To realize the potential of materials comprising living organisms, bioengineers require a holistic understanding of the reciprocal relationship between environmental conditions and the biochemical and biophysical processes that influence development and behaviour. Mathematical modelling has a critical part to play in managing the complexity of biological dynamical systems and attaining higher degrees of control over their trajectories and endpoints. To support the development of mycelium-based engineered living materials, this paper reviews the literature of growth models for filamentous fungi with emphasis on the connection between morphogenesis and metabolism.

Original language	English
Journal	Research Directions: Biotechnology Design
Volume	2
Issue number	e11
Pages (from-to)	1-16
Number of pages	16
ISSN	2752-9452
DOIs	https://doi.org/10.1017/btd.2024.10
Publication status	Published - 30 Sept 2024

Keywords

Engineered living materials
computational biology
growth model
morphogenesis
mycelium materials
fermentation

Artistic research

No

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10.1017/btd.2024.10Licence: CC BY-NC-SA

Modelling of morphogenesis - Carlström, Rigobello & Ayres 2024Final published version, 798 KBLicence: CC BY-NC-SA

FUNGATERIA: Enlisting synthetic fungal-bacterial consortia to produce multi-cellular mycelium-based ELMs with computational capability
Ayres, P. (PI), Rigobello, A. (Other), Colmo, C. (Other) & You-Wen, J. (Other)
EU Horizon, European Innovation Council
01/11/2022 → 31/10/2026
Project: Research

Cite this

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title = "Modelling of morphogenesis to support the design of fungal-based engineered living materials",

abstract = "To realize the potential of materials comprising living organisms, bioengineers require a holistic understanding of the reciprocal relationship between environmental conditions and the biochemical and biophysical processes that influence development and behaviour. Mathematical modelling has a critical part to play in managing the complexity of biological dynamical systems and attaining higher degrees of control over their trajectories and endpoints. To support the development of mycelium-based engineered living materials, this paper reviews the literature of growth models for filamentous fungi with emphasis on the connection between morphogenesis and metabolism.",

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AB - To realize the potential of materials comprising living organisms, bioengineers require a holistic understanding of the reciprocal relationship between environmental conditions and the biochemical and biophysical processes that influence development and behaviour. Mathematical modelling has a critical part to play in managing the complexity of biological dynamical systems and attaining higher degrees of control over their trajectories and endpoints. To support the development of mycelium-based engineered living materials, this paper reviews the literature of growth models for filamentous fungi with emphasis on the connection between morphogenesis and metabolism.

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KW - computational biology

KW - growth model

KW - morphogenesis

KW - mycelium materials

KW - fermentation

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JO - Research Directions: Biotechnology Design

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Modelling of morphogenesis to support the design of fungal-based engineered living materials

Abstract

Keywords

Artistic research

Access to Document

Projects

FUNGATERIA: Enlisting synthetic fungal-bacterial consortia to produce multi-cellular mycelium-based ELMs with computational capability

Cite this